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Fluttershy arrive at the Peaks of Peril train station, a deranged ticket-selling pony warns them that only uncharted territory and wild beasts await them beyond the station. Applejack wants to reach the top of the Peaks as soon as possible, which involves trekking through miles of hazardous terrain, but Fluttershy stops to interact with the local animals. After a brief breakdown in communication, Fluttershy shows Applejack a shortcut through the mountains that the animals told her about. Applejack and Fluttershy meet the silent Kirin. Applejack and Fluttershy end up in a small village where they encounter the pony-like Kirin. However, when they try to communicate, the Kirin are completely silent and expressionless, responding only to yes-or-no questions. Unable to figure out what the friendship problem is, Applejack asks if there's anyone in the area that she can talk to, and the Kirin point her on a path leading out of the village. Applejack decides to investigate while Fluttershy stays in the village to try and get more information from the Kirin.The not-so-silent Kirin[] Applejack meets Autumn Blaze, the only Kirin that talks. On the outskirts of the Kirin village, Applejack runs into yet another Kirin. She gets frustrated when this Kirin appears just as silent as the others, but the Kirin is revealed to actually be very talkative. Excited to finally be able to talk to someone, the Kirin introduces herself as Autumn Blaze and takes Applejack to her small cottage home that oversees the entire mountain range. She states that she hasn't talked to anyone ever since she and her fellow Kirin took a vow of silence.Through song, Autumn Blaze explains that the Kirin were once very sociable creatures that loved to talk, sing, and tell jokes. However, a fight broke out between two Kirin one day, and hurtful words were exchanged. The two Kirin's bodies were ignited in fire by their anger, and their arguing quickly spread to the rest of the village, causing everything to go up in flames. To prevent this from happening again, the village leader Rain Shine ordered the Kirin to step through the Stream of Silence, suppressing their voices and emotions. The Kirin are the Nirik. Though the village was rebuilt and peace was restored, Autumn Blaze grew bored of the endless silence. One day, she stumbled into a bed of foal's-breath flowers, and she brewed them into a tea that restored her ability to speak. Once again able to express herself vocally, she tried numerous times to talk to her friends, but they rejected her. Rain Shine eventually forced Autumn Blaze to choose between staying with the Kirin in silence or keeping her voice and leaving the village, and Autumn chose to

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BEDMINSTER, N.J., March 31, 2021 /PRNewswire/ -- Kyowa Kirin, Inc., an affiliate of Kyowa Kirin Co., Ltd. (Kyowa Kirin, TSE: 4151) a global specialty pharmaceutical company, today announced a key milestone in its North American Business Integration (NABI) initiative; specifically, the merger of its Kyowa Kirin Research and Kyowa Kirin Development companies into Kyowa Kirin, Inc. The outcome of this merger is a simpler business structure for the organization and a common set of processes and systems to enhance the productivity and collaborations across North America discovery, development and commercial functions. This new structure will enable the region's continued rapid growth and contributions toward the global organization's New 2030 Vision, with a steady focus on creating and delivering novel medicines for patients.All organizational changes under the NABI initiative take effect on April 1, 2021. Kyowa Kirin Canada, Inc. and BioWa, Inc., both maintain their current structure as subsidiaries of Kyowa Kirin, Inc. and Kyowa Kirin USA Holdings, Inc. respectively. A management agreement between Kyowa Kirin, Inc. and each subsidiary provides for access to key business services."We've received several FDA approvals since 2018 and continue to see great promise in our late-stage global pipeline. The organizational changes we are making through NABI will help Kyowa Kirin North America deliver the full value of these opportunities," says Gary Zieziula, President, Kyowa Kirin North America. "Through NABI, we're working to enable more efficient collaborations and business support for the functions that discover, develop and deliver first-in-class medicines that can have a profound impact on patients' lives."Between 2017 and 2020, annual revenues from KKNA medicines have grown from $25M to more than $500M. The NABI initiative will further serve KKNA in its rapid growth and expansion into new markets, including Canada, and is aligned with Kyowa Kirin's global priorities to: Maximize the full value of the organization's portfolio to address patient needs Leverage cutting-edge science and expertise in biotechnology, including antibody engineering, to build a pipeline that will drive global business growth beyond 2025 Pursue world-class product quality and operational excellence Strengthen the organization with diverse talent and digital systems "This major initiative will unify our way of thinking and help KKNA navigate an exciting but rapid growth trajectory," said Tara D'Orsi, Executive Vice President, General Counsel and Chief Compliance Officer, Kyowa Kirin North America. "With the integration of the North America-based entities, we will now utilize common processes, systems and documentation to support workflow across functions. We believe this will help us conduct business with enhanced speed, compliance and teamwork, which is key to our mission to deliver medicines that have a profound impact for patients." In addition to the integration of legal entities, KKNA has further strengthened its leadership team in 2021